Most people with AERD get frequent sinus infection. This means that antibiotics are a pretty common part of living with the disease. There are a variety of antibiotics that work for the sinuses, and depending on the bug growing in there, the doctor might choose one antibiotic over another, and sometimes treat for a longer period of time than for a “normal” infection.
Many flare ups of AERD are triggered by a virus infection. So at least in the initial phases of a flare up, it is not likely that antibiotics will be very effective. Antibiotics do not work at all for virus infections. But because the sinuses are abnormal, it isn’t uncommon for a virus infection flare up to turn into a bacterial infection that does need to be treated with antibiotics.